Journal article
Increased innate immune responses in adolescents with obesity and its relation to subclinical cardiovascular measures: An exploratory study
Siroon Bekkering, Christoph Saner, Boris Novakovic, Toby Mansell, Danielle K Longmore, Zoe McCallum, Anne-Louise Ponsonby, Markus Juonala, Mihai G Netea, Matthew A Sabin, Richard Saffery, Niels P Riksen, David P Burgner
iScience | Elsevier | Published : 2024
Abstract
Cardiometabolic risk accrues across the life course and childhood and adolescence are key periods for effective prevention. Obesity is associated with inflammation in adults, but pediatric data are scarce. In a cross-sectional and longitudinal study, we investigated immune cell composition and activation in 31 adolescents with obesity (41.9% male, BMIz>2.5, 14.4 years) and 22 controls with healthy weight (45.1% male, −1.5
Grants
Awarded by Dutch Research Council
Awarded by Dutch Heart Foundation
Awarded by Dutch Heart Foundation (CVON IN CONTROL)
Awarded by Dutch Heart Foundation in the Hague
Awarded by European Research Council (ERC) Advanced Grant
Awarded by National Health and Medical Research Council (NHMRC, Australia) Investigator Grant
Awarded by NHMRC Senior Research Fellowship
Funding Acknowledgements
S.B. is supported by the Dutch Research Council (452173113) and the Dutch Heart Foundation (2018T028) . N.P.R., M.G.N., and D.P.B. are supported by the Dutch Heart Foundation (CVON IN CONTROL, CVON2018-27) . N.P.R. is supported by a grant of the ERA-CVD Joint National Call 2018, which is supported by the Dutch Heart Foundation in the Hague (JTC2018, project MEMORY; 2018T093) . MGN is supported by an European Research Council (ERC) Advanced Grant (#833247) and a Spinoza Grant of the Netherlands Organisation for Scientific Research. Funding for the PAID platform was obtained from the National Health and Medical Research Council of Australia, the Australian Research Council, Arthritis Australia, Diabetes Australia, Rebecca L. Cooper Medical Research Foundation, LEW Carty Charitable Fund, ANZ Medical Research and Technologies in Victoria Fund, Equity Trustees Lynne Quayle Charitable Trust Fund, the Australian Acadamy of Science, The Victorian State Government Operational Infrastructure Support Program and the Murdoch Children's Research Institute Internal Grant Scheme. A.L.P., D.P.B., and B.N. are supported by a National Health and Medical Research Council (NHMRC, Australia) Investigator Grant (1110200, 1175744, APP1173314 resp.) . R.S. is supported by an NHMRC Senior Research Fellowship (1045161) . T.M. is supported by an ECR Fellowship of the Murdoch Children's Research Institute. Research at the Murdoch Children's Research Institute is supported by the Victorian Government's Operational Infrastructure Program. The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.